Fibroblasts are the most common cells of connective tissue in animals. Fibroblasts have a branched cytoplasm surrounding an elliptical, speckled nucleus having two or more nucleoli. Active fibroblasts can be recognized by their abundant rough endoplasmic reticulum (RER).

ATCC offers a variety of products for fibroblast culture, including normal human dermal fibroblasts (NHDF), media, and growth kits to support either low-serum or serum-free cell growth. To improve your clinically relevant respiratory research, we offer primary fibroblast primary cells from COPD, asthma, fibrosis, and cystic fibrosis.

2022年6月28日 · Fibroblasts are specialized cells in the body essential for the structure of tissues. They produce proteins that make up the components of the extracellular matrix (ECM), which serves as a scaffolding for other cells. This makes fibroblasts important components of connective tissue, the fibrous material that holds organs and tissues in place.

2024年9月19日 · By integrating fibroblast single-cell data from 517 human samples across 11 tissues and 43 healthy/disease conditions, our study reveals the underappreciated transcriptional heterogeneity of fibroblasts, identifies 20 robust fibroblast subtypes, and provides an in-depth characterization of their molecular and functional phenotypes, lineage ...

We summarize their development, lineages, functions, and contributions to fibrosis in four fibroblast-rich organs: skin, lung, skeletal muscle, and heart. We propose that fibroblasts are uniquely poised for tissue repair by easily reentering the cell cycle and exhibiting a reversible plasticity in phenotype and cell fate.

2 天之前 · Fibroblasts secrete collagen proteins that help maintain the structural framework of tissues. They also play an important role in healing wounds. Obtained from a person through a simple skin biopsy, fibroblasts can be grown in the laboratory for use in genetic and other scientific studies of that individual.

成纤维细胞[1][2] （fibroblast）又称 纤维母细胞，是一种广泛存在于 疏鬆結締組織 或 纤维结缔组织 内，由中胚层来源的 细胞 [3]，能够分泌 胶原 和其他 细胞外基质 以维持结缔组织结构的完整性，在间质更新和创伤修复中发挥重要作用。 成纤维细胞的形态多样，有梭形、多突的纺锤形、大多角形和扁平星形等。 成纤维细胞最初由德国 病理学家 鲁道夫·菲尔绍 与法国 解剖学家 马蒂亚斯·杜瓦尔 于19世纪中叶描述 [4]。 成纤维细胞与 伤口愈合 [5] 、 纤维化 [6] 等生理学或病理学过程 …

2023年5月1日 · Fibroblasts are elongated, disc-like structures that are not readily visible upon standard light microscopy evaluation. Usually, only the nucleus is visible in proximity to collagen fibers. Fibroblasts possess long, thin, pale-staining processes that form the …

2021年7月22日 · We summarize their development, lineages, functions, and contributions to fibrosis in four fibroblast-rich organs: skin, lung, skeletal muscle, and heart. We propose that fibroblasts are uniquely poised for tissue repair by easily reentering the cell cycle and exhibiting a reversible plasticity in phenotype and cell fate.

Fibroblasts are spindle-shaped mesenchymal cells found in the interstitial spaces. They are the primary source of extracellular matrix proteins, which provide a tissue scaffold and play a key role in cell phenotype determination and function.