FOXP1 drives osteosarcoma development by repressing P21 …
2021年3月14日 · Knocking down FOXP1 by siRNA stimulated promoter activity of RB gene (A) and P21 gene (C), whereas FOXP1 overexpression inhibited RB (B) and P21 (D) promoter …
FOXP1 drives osteosarcoma development by repressing P21 and RB ... - PubMed
Taken together, we demonstrate that FOXP1, which is transactivated by ERK/JNK-c-JUN/c-FOS, drives osteosarcoma development by regulating the p53-P21/RB signaling cascade, …
FOXP1 通过抑制 P53 下游的 P21 和 RB 转录驱动骨肉瘤的发 …
FOXP1 在骨肉瘤细胞系中的过表达和敲低表明 FOXP1 促进增殖、肿瘤球形成、迁移和侵袭，并抑制失巢凋亡。 从机制上讲，FOXP1 充当 P21 和 RB（视网膜母细胞瘤蛋白）转录的阻遏物， …
14‐3‐3σ/Stratifin and p21 limit AKT‐related malignant progression …
2024年6月13日 · Despite p53 loss, 14-3-3σ expression persisted in well-differentiated squamous cell carcinomas (wdSCCs) and alongside elevated p21, limited malignant progression via …
The Fos family of transcription factors and their role in ...
2005年11月1日 · C-Fos expression correlated significantly with cell-cycle promoters (cyclins E and B1, cdk2 and cdk4) and cell-cycle inhibitors (p16, p21, Rb). The latter proteins are often …
Regulation of Jun and Fos AP-1 transcription factors by JNK MAPKs ...
2021年9月1日 · AP-1, a mammalian dimeric transcription factor composed of Jun, Fos or Activating Transcription Factor (ATF) subunits, often binds to 12- O -tetradecanoylphorbol 13 …
Differentiation-induced skin cancer suppression by FOS, p53, and …
2012年7月9日 · Furthermore, Wnt3 and Wnt4 downregulation in Fos -deficient papillomas confirmed NOTCH1-induced, p21-dependent suppression of Wnt signaling (ref. 37 and data …
PTEN ablation in RasHa/Fos skin carcinogenesis invokes p53 …
2013年9月16日 · These data demonstrate that rapid early epidermal responses to rasHa/fos/ΔPTEN co-operation involve induction of p53/p21 to alter differentiation and divert …
EGFR、HER2、c-jun、c-fos、P21、P16、P53在非小细胞肺癌中的 …
目的 探讨EGFR、HER2、c-jun、c-fos、P21、P16、P53在非小细胞肺癌 (NSCLC)中的表达及临床病理特征.方法 采用荧光原位杂交技术 (FISH)和免疫组织化学法 (SP)检测64例非小细胞肺癌 …
Gene expression profiles induced by growth factors in
2014年7月1日 · Expression levels of key genes involved in cell growth and differentiation (CDH11, TNFRSF11B, RUNX2, POSTN, ALP, WNT5A, LEF1, HSPA5, FOS, p21) were monitored …