CREB has been confirmed to be involved in the transactivation of GPX4 [18, 20, 37] to further identify VTN-regulated GPX4-mediated ferroptosis that could be attributed to CREB. As shown in...

2023年4月10日 · GPX4 transcription is stimulated by CREB elevated in lung adenocarcinoma through the CREB-E1A binding protein P300 (EP300) binding [63]. Human GPX4 promoter is also transcriptionally regulated by its 5′-upstream E-box region binding with ZEB1, the transcriptional factor regulating cell plasticity and EMT for cancer metastasis [ 16 , 64 ].

2021年4月13日 · 据观察，creb 通过结合谷胱甘肽过氧化物酶 4 (gpx4) 的启动子区域来抑制脂质过氧化，并且这种结合可以通过 e1a 结合蛋白 p300 (ep300) 增强。 CREB 中的 bZIP 结构域和 EP300 中的 CBP/p300-HAT 结构域对于 LUAD 细胞中的 CREB-EP300 结合至关重要。

It was observed that CREB suppressed lipid peroxidation by binding the promoter region of glutathione peroxidase 4 (GPX4), and this binding could be enhanced by E1A binding protein P300 (EP300). The bZIP domain in CREB and the CBP/p300-HAT domain in EP300 were essential for CREB-EP300 binding in LUAD cells.

It was observed that CREB suppressed lipid peroxidation by binding the promoter region of glutathione peroxidase 4 (GPX4), and this binding could be enhanced by E1A binding protein P300 (EP300). The bZIP domain in CREB and the CBP/p300‑HAT domain in EP300 were essential for CREB‑EP300 binding in LUAD cells.

2023年9月27日 · The acetyltransferase E1A binding protein P300 (EP300), for example, promotes the binding of transcription factors to target genes by increasing H3K27ac . Most typically, EP300 binds to the bZIP domain of CREB via its CBP/p300-HAT domain to form a transcription-promoting complex .

CREBBP/EP300 participate in tumor immune regulation by modulating the function of immune cells through various pathways. T regulatory cells (Tregs) are a subset of CD4 + T-cells with significant immunosuppressive effects.

Download scientific diagram | Clinical significance of CREB, EP300, GPX4 and 4-HNE. (A-D) Relative (A) CREB, (B) GPX4, (C) EP300 mRNA levels and (D) 4-HNE concentration in 36 paired LUAD tissues ...

2021年4月2日 · It was observed that CREB suppressed lipid peroxidation by binding the promoter region of glutathione peroxidase 4 (GPX4), and this binding could be enhanced by E1A binding protein P300...

2023年9月27日 · The acetyltransferase E1A binding protein P300 (EP300), for example, promotes the binding of transcription factors to target genes by increasing H3K27ac . Most typically, EP300 binds to the bZIP domain of CREB via its CBP/p300-HAT domain to form a transcription-promoting complex .