Chemokine receptors are G protein-coupled receptors containing 7 transmembrane helices [5] that are found predominantly on the surface of leukocytes. Approximately 19 different chemokine receptors have been characterized to date, which share many common structural features.

This guide gives a broad overview of the chemokine and chemokine receptor families; summarizes the complex physical interactions that occur in the chemokine network; and, using specific examples, discusses general principles of chemokine function, focusing particularly on their ability to direct leukocyte migration.

2021年3月15日 · 趋化因子Chemokines是细胞因子中的一个大家族。在人类中已经发现有四十多个成员。 1 趋化因子的发现历史 第一个趋化因子是1977年由Walz及其同事发现的。它是一种促凝和血管抑制因子，称为血小板因子4，现在更名为C…

Chemokine receptors are composed of seven transmembrane domain–containing G protein–coupled receptors (GPCRs) and are named on the basis of the secondary structure of their respective ligand binding partners. 1 Approximately 40 kDa in size, chemokine receptors signal through several G protein subunits, leading to a diverse array of ...

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein-coupled heptahelical chemokine receptors. They are best known for their ability to stimulate the migration of cells, …

The control of cell migration by chemokines involves interactions with two types of receptors: seven transmembrane chemokine-type G protein-coupled receptors and cell surface or extracellular matrix associated glycosaminoglycans. Coordinated ...

2018年4月10日 · This guide gives a broad overview of the chemokine and chemokine receptor families; summarizes the complex physical interactions that occur in the chemokine network; and, using specific examples, discusses general principles of chemokine function, focusing particularly on their ability to direct leukocyte migration.

2002年2月1日 · This review describes in great detail the discovery of the chemokine receptors as essential co-receptors for HIV infectivity, and also provides an excellent background of HIV virology.

Chemokine receptors are a superfamily of GPCRs that control immune cell behavior; they promote chemotaxis, cell adhesion, and mediator release (see also Chapter 7). The chemokine receptor superfamily is divided into four classes based on the chemokine/ligand interaction motif to which they bind (CC, CXC, CX3C, or XC).

2001年12月1日 · Chemokines exert their biological effects by binding to cell surface receptors. Chemokine receptors belong to a superfamily of serpentine proteins that signal through coupled heterotrimeric G proteins (Fig. 1).