Cephalosporins are the largest group of beta-lactam antibiotics, cover a broad range of organisms, are generally well-tolerated, are easy to administer, and are thus frequently used. The classification, spectrum of activity, and pharmacology of the cephalosporins will be reviewed here.

First-generation cephalosporins are active predominantly against Gram-positive bacteria, such as Staphylococcus and Streptococcus. [ 7 ] . They are therefore used mostly for skin and soft tissue infections and the prevention of hospital-acquired surgical infections. [ 8 ] .

2024年2月17日 · Cephalosporins are β-lactam antimicrobials used to manage various infections caused by both gram-positive and gram-negative bacteria. The 5 generations of cephalosporins demonstrate efficacy in treating skin and soft tissue infections, pneumonia, meningitis, and …

2019年1月28日 · Cephalosporins are a class of antibiotics used to treat a variety of bacterial infections. Learn about the different generations of cephalosporins as well as their potential side effects.

2023年10月11日 · Cephalosporins have three different mechanisms of action. They are: Binding to specific penicillin-binding proteins. Inhibition of cell wall synthesis. Activation of autolytic (self-destructive) enzymes in the bacterial cell wall. Cephalosporins are divided into five generations.

2023年4月12日 · There are five “generations” of cephalosporins, with each generation differing slightly in their antibacterial spectrum (ie, how effective they are at killing certain types of bacteria).

2007年5月5日 · Cephalosporins are classified into five "generations" (Table 1) based on their spectrum of antimicrobial activity. Each newer generation of cephalosporins has significantly broader gram-negative antimicrobial spectrum than the preceding generation, and in most cases decreased activity against gram-positive organisms.

Cephalosporins are bactericidal beta-lactam antibiotics. They inhibit enzymes in the cell wall of susceptible bacteria, disrupting cell wall synthesis. There are multiple generations of cephalosporins. (See also Overview of Antibacterial Medications.)

Cephalosporins are β-lactam antibiotics, which are grouped into four generations according to their antibiotic spectrum of activity (Simon and Stille, 1997). The first generation has mainly gram-positive activity.

Cephalosporins are a subclass of antibiotics called beta-lactam antibiotics (antibiotics that have a chemical structure called a beta-lactam ring). Beta-lactam antibiotics also include carbapenems, monobactams, and penicillins. There are several classifications or generations of cephalosporins.