Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). [7] It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis. [7]

2022年5月24日 · What COX-2 inhibitors are available? Celecoxib (Celebrex®) is the only COX-2 inhibitor available in the U.S. Etoricoxib (Arcoxia®) and parecoxib (Dynastat®) are available in countries outside the U.S. Other COX-2 inhibitors have been taken off the U.S. market because of safety concerns.

2024年2月28日 · The mechanism of celecoxib's action is due to the selective inhibition of cyclooxygenase-2 (COX-2), responsible for prostaglandin synthesis, an integral part of the pain and inflammation pathway. This pharmacologic activity gives celecoxib its analgesic, anti-inflammatory, and antipyretic effects.

How Celecoxib Works. As a COX-2 inhibitor, celecoxib blocks an inflammation-promoting enzyme called COX-2. Medications known as COX-2 inhibitors were developed to work as well as traditional NSAIDs but with fewer stomach problems. However, many reports of heart attacks and stroke prompted the FDA to re-evaluate the risks and benefits of the COX-2s.

In animal models of inflammation and pain, celecoxib has shown marked suppression of PG production and inflammation compared with indomethacin, the standard COX-1/COX-2 inhibitor. In clinical trials, celecoxib dosed at 100, 200, and 400 mg BID was found to significantly reduce the signs and symptoms of rheumatoid arthritis (RA) and osteoarthritis.

2023年8月23日 · At lower doses, meloxicam is more similar to Celebrex (celecoxib) than it is to other NSAIDs, like ibuprofen or naproxen, because it is relatively selective for the COX-2 enzyme. But at higher doses, even within the prescribed range, meloxicam can inhibit both COX-1 and COX-2 enzymes, which may lead to side effects like stomach ulcers or bleeding.

Coxibs such as Celebrex (celecoxib), by selectively inhibiting the overexpressed COX-2, allow p53 to work properly. Functional p53 allows DNA damaged neuroblastoma cells to commit suicide through apoptosis, halting tumor growth.

The selective COX-2 inhibitor, celecoxib, shows a complex but important pharmacogenomics profile. The use of this highly effective anti-inflammatory and antitumor drug is limited by concerns about its potential for increased cardiovascular risk.

COX-2 inhibitors (coxibs) have been developed to reduce pain and inflammation without associated GI and bleeding risks. Celecoxib was the first COX-2 inhibitor introduced on the market, and it still remains so, whereas rofecoxib and valdecoxib were withdrawn due to excess cardiovascular (CV) risk.

2024年12月10日 · Nonsteroidal anti-inflammatory agent (NSAIA); selective inhibitor of cyclooxygenase-2 (COX-2). Uses for Celecoxib Osteoarthritis. Symptomatic treatment of osteoarthritis. The American College of Rheumatology (ACR) recommends topical/oral NSAIAs for treatment of osteoarthritis, among other interventions.