2018年4月30日 · Lnc-Tim3 plays a pivotal role in stimulating CD8 T exhaustion and the survival of the exhausted CD8 T cells. Mechanistically, Lnc-Tim3 specifically binds to Tim-3 and blocks its interaction with Bat3, thus suppressing downstream Lck/ NFAT1/AP-1 signaling, leading to nuclear localization of Bat3, and enhancing p300-dependent p53 and RelA ...

2018年4月30日 · Here, we show that Lnc-Tim3 is upregulated and negatively correlates with IFN-γ and IL-2 production in tumor-infiltrating CD8 T cells of HCC patients. Lnc-Tim3 plays a pivotal role in...

Furthermore, small interfering RNA targeting lncRNA-CD160 can block HBV infection progression. lncRNA-CD160 acts as an immune suppressive factor and is expressed at a high level in peripheral blood CD8 + T cells of HBV infected patients.

2024年7月5日 · We identified specific markers of CD8 Tex cells and analyzed their potential functions. Twenty-eight lncRNAs were identified as CD8 Tex-related. Based on CD8 Tex-related lncRNAs, samples were categorized into two distinct clusters, which exhibited significant differences in survival rates and immune infiltration.

2020年4月15日 · The results indicated that CD160 may serve an important inhibitory role in CD8 + T cell function. In addition, lncRNA-CD160 can mediate the TNF-α and IFN-γ secretion in CD8 + T cells and the immunity of CD8 + T cells through epigenetic regulation during hepatitis B …

LncRNA can regulate the function of CD8+ T cells in the TME through a variety of mechanisms to alter the immune response. LNC-TIM3 was found to be upregulated in tumor-infiltrating CD8 T cells from HCC patients and negatively correlated with the level of IFN-γ and IL-2 production.

Lnc-Tim-3, a NF-κB-modulating lncRNA, was uncovered by high-throughput screening of CD8 + T cells originating from TILs of HCC patient samples. Lnc-Tim-3 expression highly correlated with Tim-3 + Tex cells and specific binding of the lncRNA …

2019年1月14日 · We identify hundreds of unannotated lncRNAs and show that expression profiles of both known and novel lncRNAs are sufficient to define naive, effector, and memory CD8 + T cell subsets, implying...

Here, we show that Lnc-Tim3 is upregulated and negatively correlates with IFN-γ and IL-2 production in tumor-in ltrating CD8 T cells of HCC patients. Lnc-Tim3 plays a pivotal role in...

2024年3月12日 · Taken together, our results reveal the function of Lnc-CCNH-8 in inducing immune escape from CD8 + T-cell-mediated killing by up-regulating PD-L1 in a miR-217/miR-3173-dependent manner, which also reveals a novel mechanism of PD-L1 regulation in HCC, and exosomal Lnc-CCNH-8 can serve as a predictive marker for immunotherapy response in HCC.