2020年7月28日 · 抗原结合部位 位于V区顶端，由每条链上三个高度可变的CDR loop组成。 在αβ链侧面也存在一些 糖基化 修饰，它们不直接参与抗原肽识别，但与CD3/4/8受体结合有一定关系。 与B细胞不同的是，TCR只有一个抗原结合区域，且只能连接在细胞表面，不能作为分泌蛋白离开细胞；抗原识别方面，TCR识别的是经过抗原呈递细胞处理、结合在 MHC分子 上的肽段，而BC. T细胞是由造血干细胞分化而来的一种淋巴细胞 (lymphocyte)，在发育早期阶段由骨髓迁移 …

2022年10月10日 · 在 dn 区室内，通过 cd44和 cd25标记物的差异表达来标记四个连续阶段: dn1(cd25-cd44hi) ，dn2(cd25 + cd44 +) ，dn3(cd25 + cd44 -)和 dn4(cd25-cd44 -)。 属于主要 αβT 细胞谱系的细胞进一步发展至双阳性 CD4 + CD8 + (DP)阶段，其中 αβ 肿瘤细胞受容体(TCR)复合物首先在细胞表面表达 ...

2024年11月11日 · cd44 与 cd62l 作为 t 细胞表面极为关键的两种分子标记，以调控细胞迁移、黏附以及活化信号传导等多种机制的方式，深度参与到 t 细胞的活化、迁移以及记忆反应之中。

The DN population can be further sub-divided by the expression of CD44 (an adhesion molecule) and CD25 (Interleukin-2 receptor α chain), Figure 1 shows the ordered expression of these markers. Cells that lack expression of CD44, but express CD25 (DN3) undergo a …

We have assessed the requirement for CD44 in T cell development and mature T cell function by analyzing mice in which CD44 –/– and WT cells were produced simultaneously. In mixed (CD44 –/– + CD44 +/+) bone marrow chimeras, production of CD44 –/– T cells was shown to be reduced compared to WT cells due to inefficient intrathymic development.

1993年5月15日 · We have subdivided mouse CD4-CD8-CD3- triple-negative (TN) thymocytes into four subsets based upon expression of CD44 and CD25, including CD44+CD25-, CD44+CD25+, CD44-CD25+ and CD44-CD25-.

2004年1月1日 · Thymocyte differentiation is characterized by the expression of well-defined cell-surface markers, including CD4, CD8, CD44 (or CD117) and CD25, as well as the status of the T-cell receptor...

1993年5月15日 · We have subdivided mouse CD4-CD8-CD3- triple-negative (TN) thymocytes into four subsets based upon expression of CD44 and CD25, including CD44+CD25-, CD44+CD25+, CD44-CD25+ and CD44-CD25-. Characterization of these cells revealed several features distinct to each subset, in particular the expression …

2022年10月31日 · The absolute number of ETPs (CD44 + cKit + CD25 –), the earliest T cell progenitors, and their DN2 progeny (CD44 + cKit + CD25 +), were significantly decreased in both mutants compared with...

2009年10月23日 · We present herein the following key findings: 1) the surface expression of CD44 in mouse thymocytes positively correlated with that of Foxp3; 2) CD4 + CD25 + CD44 + T reg cells expressed higher levels of IL-10 and were more potent in suppressing effector T cell proliferation than were CD4 + CD25 + CD44 - cells; and 3) blocking IL-10 aborogated s...