2002年1月11日 · These novel spiro-fused (C5)-isoxazolino- (C4)-pyrazolones were confirmed by spectroscopic analysis as well as single-crystal X-ray of 5. We also concluded that all condensations/cycloeliminations, except with hydrazine itself, were more effective with catalysts or higher reaction temperatures.

2023年11月6日 · Biologically active compounds have pyrazole rings. With limited facilities to investigate more experimental acceptor abilities, molecular docking became crucial for studying the binding...

A wide range of biological activity also shows by 2-pyrazoline derivatives such as antimicrobial, analgesic agent, anticancer agent, and antitubercular agent [6-10], which stimulate the research activity in this field. Isoxazoline derivatives have been reported in the literature to possess antibacterial, antifungal, and antiviral [11-13 ...

2020年10月7日 · Herein we review synthetic strategies toward isoxazolines and the role these efforts have had in enhancing the biological activity of natural products and synthetic compounds such as antitubercular agents, COX-1 inhibitors, COX-2 inhibitors (e. g., valdecoxib), nicotinic receptor modulators, and MIF inhibitors.

Download scientific diagram | Biologically active isoxazoline/ isoxazole derivatives. from publication: Microwave induced synthesis of new class of pyrano isoxazoline and isoxazole...

2011年7月7日 · Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with mono-substituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles.

It has been established that pyrazolines and their analogs are pharmacologically active scaffolds. The pyrazoline moiety is present in several marketed molecules with a wide range of uses, which has established its importance in pharmaceutical and agricultural sectors, as well as in industry.

Pyranopyrazole derivatives have a vital role in the class of organic compounds because of their broad spectrum of biological and pharmacological importance. Our current goal is the [3 + 3]...

2011年8月26日 · As a result, we developed an efficient and divergent synthesis of isoxazoles 2 ( Scheme 1, path D) and spiro-fused pyrazolin-5-ones 3 ( Scheme 1, path E) under very mild conditions. Herein, we wish to report our experimental results and present proposed mechanisms involved in the ring-opening and/or cyclization reactions. 2. Results and discussion.

2015年4月1日 · Spiro-isoxazoline derivatives bearing a p-chloro or an o-dichloro aromatic substituent at the 3-position of the isoxazoline showed considerable antitumor activities in all four cell lines with IC 50 value ranging from 43μM to 56μM.