2024年11月24日 · Atypical femoral fractures, also known as bisphosphonate-related proximal femoral fractures, are an example of insufficiency fractures, although the direct causative link remains somewhat controversial 2. The atypical fracture pattern occurs in the femur shaft and may be unilateral or bilateral.

Atypical Femur Fracture (AFF) Overview • Low energy femoral shaft fractures with a characteristic appearance • Caused by a combination of unfavorable femoral anatomy (varus, anterior bow) and impaired bone healing/remodeling • Frequently (but not …

2020年8月19日 · We found that the risk of atypical femur fracture increased significantly with longer duration of bisphosphonate treatment — particularly beyond 5 years of use — even after multivariate ...

2018年11月1日 · In this article, we examine the evidence on bisphosphonate-associated atypical femoral fractures, including risks, pathogenesis, treatment, and prevention. An atypical femoral fracture is a transverse fracture of the femoral shaft (diaphysis), defined by both clinical criteria and radiographic appearance.

Atypical femoral fractures (AFF) are a rare type of femoral stress fracture recently described, potentially associated with prolonged bisphosphonate therapy. Evidence-based recommendations regarding diagnosis and management of these fractures are ...

2020年8月21日 · This paper reviews our current understanding of atypical femur fractures, their relationship to antiresorptive osteoporosis medications, and proposed strategies for management, in order to inform clinical decision making about the optimal use and duration of medical therapy for the treatment of patients with osteoporosis or at high risk for ...

2022年6月14日 · 非典型股骨骨折（Atypical Femur Fractures） 是由长期服用双磷酸盐药物导致的股骨干部骨折，其具有与创伤性股骨干骨折完全不同的特点。 2013年，ASBMR工作小组对非典型股骨骨折作出了如下诊断标准： 1.骨折部位. 骨折位于股骨干部，股骨小转子以下，股骨髁以上。 ⑤ 骨内膜或者骨膜增厚。 3.次要诊断标准. ① 骨干皮质广泛增厚； ② 双侧股骨干骨折； ③ 有前驱症状，如腹股沟疼痛； ④ 延迟愈合。 ① 起自股骨颈或粗隆间的骨折，向干部延伸； ② …

Key features of atypical femoral fractures, essential for the diagnosis, are: location in the subtrochanteric region and diaphysis; lack of trauma history and comminution; and a transverse or short oblique configuration.

2017年4月10日 · Atypical femoral fractures are stress or insufficency fractures occurring in the femoral shaft. Bisphosphonates inhibit osteoclasts and decrease bone remodelling that may lead to accumulation of microdamage and stress fracture in the femoral shaft (below the lesser trochanter and proximal to the supracondylar flare; Figure 1A).1, 3

Atypical femoral fractures are often attributed to the use of anti-resorptive medications such as bisphosphonates (BP). Whilst they have proven effects on fragility fracture prevention, clinical and laboratory evidence is evolving linking BP-related suppression of bone …