Habitual chewing of "betel nut" preparations constitutes the fourth most common human self-administration of a psychoactive substance after alcohol, caffeine, and nicotine. The primary active ingredient in these preparations is arecoline, which comes from the areca nut, the key component of all such preparations.

Arecoline is the primary active ingredient responsible for the central nervous system effects of the areca nut. Arecoline has been compared to nicotine; however, nicotine agonizes nicotinic acetylcholine receptors, whereas arecoline is primarily a partial agonist of muscarinic acetylcholine receptors, [4] [5] leading to its parasympathetic effects.

2022年9月6日 · Arecoline, the primary alkaloid of betel nut, is a muscarinic acetylcholine receptor agonist producing cholinergic effects on the parasympathetic nervous system and a psychoactive agent, contributing to the psycho-stimulating effects.

Arecoline, the major pyridine alkaloid from the Areca nut, was also a weak partial agonist of the α4β2 nAChR, but did not show the same level of subsequent inhibition of the ACh response. 21 We have since found that the inhibitory component is greater than 10 kDa in molecular weight, and it will be pursued in separate work.

Areca nut, also known as betel nut, is the seed of the palmaceous Areca catechu tree. It is a primary ingredient in betel quid.

2024年11月27日 · Arecoline, which has attracted attention for its therapeutic potential in the treatment of mental illness and the relief of gastrointestinal disorders, is the main active alkaloid in the areca nut. However, in 2020, the IARC said that …

2019年5月21日 · Results: Both arecoline- and guvacoline-activated muscarinic acetylcholine receptors (mAChR), while only arecoline produced significant activation of nicotinic AChR (nAChR). We characterized four additional arecoline-related compounds, seeking an analog that would retain selective activity for a α4* nAChR, with diminished effects on mAChR and ...

2013年8月15日 · Separation of these bioactive polyphenols from toxic constituents could propel the safe and beneficial use of betel nut; also it will help arecanut processing industries to produce arecoline-free products.

2024年10月30日 · The nut is commonly referred to as "betel nut" because it is often wrapped in betel leaves for chewing. Areca nuts and food products containing areca nuts are imported to the US, often...

2005年6月13日 · An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice.