Hepatocyte apoptosis involves two fundamental pathways: the extrinsic pathway, which transmits death signals by the death receptor (DR), and the intrinsic pathway, which is initiated by intracellular stimuli. The extrinsic apoptotic pathway is activated by the binding of the death ligand to DRs on the plasma membrane.

2014年1月16日 · Mechanisms of hepatic apoptosis are complicated by multiple signaling pathways. The progression of liver disease is affected by the balance between apoptotic and antiapoptotic capabilities....

Liver cells, especially hepatocytes and cholangiocytes, are particularly susceptible to death receptor-mediated apoptosis, given the ubiquitous expression of the death receptors in the organ. In a quite unique way, death receptor-induced apoptosis in these cells is mediated by both mitochondrial and lysosomal permeabilization.

2024年6月3日 · Apoptosis represents a form of energy-dependent cell death (programmed cell death) that typically occurs as death of individual hepatocytes. In contrast to necrosis, apoptosis is a regulated and genetically controlled process.

2018年9月24日 · We focus on the role of apoptosis and necroptosis in acute liver injury, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and liver cancer, and possible translations...

Apoptosis represents a form of energy-dependent cell death (programmed cell death) that typically occurs as death of individual hepatocytes. In contrast to necrosis, apoptosis is a regulated and genetically controlled process.

Apoptosis has been documented as a frequent hurdle phenomenon that occurs in human hepatocytes during isolation, storage, infusion and after engraftment within the recipient liver parenchyma. Apoptosis is an active form of cell death that involves programmed cellular machineries leading to a progres …

2020年1月24日 · Hepatocyte apoptosis is a key mediator of liver injury and inflammation in most forms of liver disease. Multiple apoptotic pathways are activated by a given injurious stimulus in a vulnerable hepatocyte.

2016年12月29日 · This review summarizes recent research on the mechanism of hepatocyte apoptosis involving the classical extrinsic and intrinsic apoptotic pathways, endoplasmic reticulum stress, and oxidative stress-induced apoptosis. We emphasized the major causes of apoptosis according to the characteristics of different liver diseases.

Our finding of neutrophil burrowing into and clearing of apoptotic hepatocytes under physiological conditions reveals a fundamental mechanism for the removal of effete hepatocytes, helps to solve some mysteries surrounding the apoptotic clearance process, …