Alkaline phosphatase, placental-like 2 is a protein that in humans is encoded by the ALPPL2 gene. [5] There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).

2020年10月15日 · To evaluate therapeutic potential of ALPPL2 targeting, an ALPPL2-targeted antibody–drug conjugate was developed and demonstrated potent and specific tumor killing in vitro and in vivo against both epithelioid and sarcomatoid mesothelioma.

2013年3月14日 · ALPPL-2 was found to be ectopically expressed in many pancreatic cancer cell lines at both mRNA and protein levels. RNA interference-mediated ALPPL-2 knockdown identified novel tumor-associated functions of this protein in pancreatic cancer cell growth and invasion.

ALPP and ALPPL2, mainly expressed in placenta and testis, form homo- and heterodimers and play key roles in nucleotide recycling. They are overexpressed on certain tumor cell types while normal tissue expression of ALPP and ALPPL2 is restricted to placenta and reproductive tissue.

2020年1月8日 · To evaluate therapeutic potential of ALPPL2 targeting, we developed an ALPPL2-targeted antibody-drug conjugate and demonstrated potent and specific tumor killing in vitro and in vivo against both epithelioid and sarcomatoid mesothelioma.

2024年3月22日 · ALPPL2 is currently being investigated as a novel therapeutic target due to its cancer-specific expression. However, our knowledge of ALPPL2 biological function in cancer is limited. Here we describe an interaction between ALPPL2 and MAPK signaling pathway in pancreatic cancer.

Su, Y., Zhang, X., Bidlingmaier, S., Behrens, C.R., Lee, N.K., and Liu, B.. ALPPL2 is a highly specific and targetable tumor cell surface antigen. Cancer Res. 2020; 20(80):4552-4564.

Millan et al. (1982) found that human testes contain trace amounts of heat-stable placentallike alkaline phosphatase. From reactivity with a monoclonal antibody to placental alkaline phosphatase and from study of enzyme inhibitors, they concluded that the testicular enzyme is separate from the placental enzyme.

Homo sapiens gene ALPPL2, encoding alkaline phosphatase, placental-like 2. [ALPPL2] There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).

2021年1月7日 · Here we identify ALPPL2 as a tumor-specific antigen expressed in a spectrum of solid tumors, including mesothelioma. ALPPL2 can act as a sole target for chimeric antigen receptor (CAR) therapy or be combined with tumor-associated antigens such as MCAM or mesothelin in synthetic Notch (synNotch) CAR combinatorial antigen circuits.