2024年3月1日 · Central to maintaining a healthy epithelium are intestinal stem cells (ISCs), which are essential for replenishing the intestinal epithelium throughout an individual’s lifespan. Recent...

Antimicrobial peptides of the alpha‐defensin family are secreted by Paneth cells and may provide protection for small intestinal stem cells against bacterial infection. The mucin glycoprotein Muc2 also appears to play an important role in regulating intestinal stem cell function.

2007年10月25日 · The Lgr5-positive crypt base columnar cell generated all epithelial lineages over a 60-day period, suggesting that it represents the stem cell of the small intestine and colon. The expression pattern of Lgr5 suggests that it marks stem cells in …

An intestinal stem cell (ISC), similar to stem cells of the mouse hematopoietic system and the hair follicle, may be broadly defined by at least two properties: the ability to maintain itself throughout long periods of time (ie, self-renewal) and the potential to generate all differentiated cell types including enterocytes, goblet cells, entero ...

2007年10月14日 · The Lgr5 (also known as Gpr49) gene is identified as a unique, single marker gene for adult stem cells and provides the first lineage tracing data for long-lived pluripotent stem cells in the ...

In the small intestine, maintenance of stem cells and appropriate differentiation into various cell lineages require Notch and Wnt signaling. Previous studies have examined these pathways individually, but how Notch and Wnt signaling work together to maintain ISCs and modulate cell fate remains unclear.

2018年11月14日 · We investigate how the niche protects and instructs intestinal stem cells, which processes drive differentiation of mature cells and how imbalance in key signalling pathways can cause human...

2013年8月7日 · Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self-renewal and differentiation. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture.

2020年3月16日 · The ability of stem cells to divide and differentiate is necessary for tissue repair and homeostasis. Appropriate spatial and temporal mechanisms are needed. Local intercellular signaling increases expression of specific genes that mediate and maintain differentiation.

2015年3月9日 · We identified stem cell markers that separate subpopulations of colony-forming cells in the small and large intestine and revealed important differences in differentiation, proliferation and disease pathways using gene expression analysis.