2024年12月25日 · Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. Interacts with SMARD1 and UNC45A.

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.

Gene ID: 5241, updated on 10-Dec-2024. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with …

The effects of progesterone are mediated by the progesterone receptor (PR), a member of the nuclear receptor superfamily of transcription factors that regulate gene expression upon hormonal stimulation.

2024年12月10日 · This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.

A Progesterone Receptor is a protein encoded by a single gene that can exist in two isoforms, A and B, with different functions. These receptors interact with specific DNA sequences called progesterone-responsive elements and are expressed in various tissues including the brain, breast, and adipose tissue.

We examine available data in different species and tissues regarding: 1) regulation of PR levels; and 2) expression profiling of progestin-regulated genes by total PRs, or their PRA and PRB isoforms.

Emerging data indicate that progesterone has multiple non-reproductive functions in the central nervous system to regulate cognition, mood, inflammation, mitochondrial function, neurogenesis and regeneration, myelination and recovery from traumatic brain injury.

The progesterone receptor (PR) gene is transcribed from one gene by two alternative promoters and translated into two different zinc-finger containing proteins, PR-A and PR-B differing by a 165-amino-acid part in the NH2-terminal region. PR-B is a potent transcriptional activator, whereas PR-A, the shorter isoform, is necessary to oppose the ...

2024年4月11日 · Regulation of progesterone receptor expression in endometriosis, endometrial cancer, and breast cancer by estrogen, polymorphisms, transcription factors, epigenetic alterations, and ubiquitin-proteasome system. Genetic variants of progesterone receptor in etiology of preterm delivery.