![](/rp/kFAqShRrnkQMbH6NYLBYoJ3lq9s.png)
HLA variation and disease | Nature Reviews Immunology
2018年1月2日 · We evaluate the scope for personalized antigen-specific disease prevention, whereby harnessing HLA–ligand interactions for clinical benefit is becoming a realistic prospect. HLA gene variation...
免疫系统之 HLA 与MHC - 知乎 - 知乎专栏
人类白细胞抗原(英语:human leukocyte antigen)- HLA是在 6号染色体短臂 上的一类基因,编码MHC蛋白质。HLA有不同的基因座,编码两大类 MHC蛋白 。 HLA高度多态性,同一种基因座还有不同的等位基因
Human Leukocyte Antigen (HLA) System: Genetics and …
The human leukocyte antigen (HLA) system is one of the most crucial host factors influencing disease progression in bacterial and viral infections. This review provides the basic concepts of the structure and function of HLA molecules in humans. ...
人類白細胞抗原 - 维基百科,自由的百科全书
人類白細胞抗原 (英語: human leukocyte antigen, 缩写 为 HLA),是編碼人类的 主要组织相容性复合体 (MHC)的基因。 其位于 6号染色体 的短臂上(6p21.31),包括一系列紧密连锁的 基因座,与人类的 免疫系统 功能密切相关。 其中部分基因编码细胞表面抗原,成为每个人的细胞不可混淆的“特征”,是 免疫系统 区分自身和异体物质的基础。 HLA基因高度 多态化,存在许多不同的 等位基因, 从而细致调控 后天免疫系统。 [來源請求] 属于 第一类MHC 的HLA(HLA-A, …
The HLA genomic loci map: expression, interaction, diversity and ...
2009年1月9日 · The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal position 6p21 that encodes the six classical transplantation HLA genes and at least 132 protein...
Major histocompatibility complex: Antigen processing and …
2013年7月18日 · The main function of HLA class I gene products (HLA-A, -B, and -C) is to present endogenous peptides to responding CD8+ T Cells while the class II coded molecules HLA-DR, -DP, and –DQ have restricted expression and process exogenous peptides for presentation to CD4+ helper T Cells.
The HLA System: Genetics, Immunology, Clinical Testing, and …
The human major histocompatibility complex HLA is located on the short arm of chromosome 6. It is known to be the most polymorphic genetic system in humans. The biological role of the HLA class I and class II molecules is to present processed ...
Association of HLA-A and Non-Classical HLA Class I Alleles
2016年10月4日 · A complete Human Leukocyte Antigen (HLA) match is associated with better long term survival in transplant patients, however the effects of HLA-A, -B and -DRB1 matching are unequal and also depend upon the organ being transplanted. HLA-A mismatches were found to have less influence on kidney allografts than HLA-B mismatches .
Nature重磅!困扰科学界50年的谜题被解开,新方法发现自身免疫 …
人类白细胞抗原(Human Leukocyte Antigen, HLA)蛋白家族参与帮助免疫细胞检测入侵病原体并区分微生物和人类蛋白,并且HLA基因在个体之间差异极大。 而自身免疫性疾病通常被认为是机体免疫系统错误识别的结果,这…
Tutorial: a statistical genetics guide to identifying HLA alleles ...
2023年7月26日 · We provide detailed guidance on performing standard quality control measures for input genotyping data and describe options to impute HLA alleles and amino acids either locally or using the web...