If diuretic-induced gout occurs, it is typically treated with a urate-lowering drug such as allopurinol. The pathogenesis, epidemiology, and an overview of treatment of diuretic-induced hyperuricemia and gout are presented in this topic.

2024年1月18日 · Gout flares (also called gout attacks) are sudden episodes of severe joint pain, usually involving redness, swelling, and tenderness of the joint. Although a gout flare typically affects a single joint, some people develop several inflamed joints at the same time.

2024年9月20日 · Canakinumab is also effective for gout flare prophylaxis. For gout flares, it is typically given as a one-time dose of 150 mg subcutaneously. (See "Gout: Pharmacologic urate-lowering therapy and treatment of tophi", section on 'Prophylaxis during initiation of …

The loop diuretics are highly protein bound and therefore enter the tubule primarily by secretion in the proximal tubule, rather than by glomerular filtration . The most commonly used loop diuretics are furosemide, bumetanide, and torsemide, which are sulfonamide derivatives.

2024年9月10日 · In patients with gout, an excess of urate can cause monosodium urate crystals to precipitate in joints or other tissues where they elicit an inflammatory response. Thus, therapy for patients with chronic gout aims to reduce serum urate concentration to a level where crystals are less likely to form.

Management for the prevention of recurrent gout flares and damage to joints and other tissues from urate crystal deposition includes drug therapy, lifestyle modifications, and other strategies for risk reduction.

2023年11月30日 · The approach to asymptomatic hyperuricemia; the pathophysiology, clinical manifestations, and diagnosis of gout; and the prevention of recurrent gout after resolution of the gout flares are discussed separately:

Combined use of loop diuretics and thiazide diuretics was associated with the highest relative risk estimates of gout (adjusted OR 4.65 [95% CI 3.51-6.16]). Current use of calcium channel blockers or losartan slightly attenuated the risk of gout in patients who took diuretics.

2024年10月28日 · Gout (monosodium urate [MSU] crystal deposition disease) is characterized biochemically by extracellular fluid urate saturation, which is reflected in the blood by hyperuricemia, with serum or plasma urate concentrations exceeding 6.8 mg/dL (approximately 400 micromol/L); this level of urate is the approximate limit of urate solubility . The ...

Diuretics, particularly thiazide-type and thiazide-like diuretics, are commonly used in the treatment of hypertension. Diuretics lower the blood pressure, at least initially, by inducing sodium and fluid loss.