CD38 - Wikipedia
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein [5] found on the surface of many immune cells (white blood cells), including CD4 +, CD8 +, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. [6]
CD38: An Immunomodulatory Molecule in Inflammation and …
2020年11月30日 · The role of CD38 in immune cells ranges from modulating cell differentiation to effector functions during inflammation, where CD38 may regulate cell recruitment, cytokine release, and NAD availability.
CD38 Gene - CD38 Molecule - GeneCards
2024年12月24日 · CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include Prolymphocytic Leukemia and Leukemia, Chronic Lymphocytic 2. Among its related pathways are NAD metabolism and Metabolism of water-soluble vitamins and cofactors.
CD38: An Immunomodulatory Molecule in Inflammation and …
2020年11月29日 · The main expression of CD38 is observed in hematopoietic cells, with some cell-type specific differences between mouse and human. The role of CD38 in immune cells ranges from modulating cell differentiation to effector functions during inflammation, where CD38 may regulate cell recruitment, cytokine release, and NAD availability.
CD38: what is it there for? - American Society of Hematology
2003年9月15日 · It is a type II transmembrane glycoprotein, the extracellular domain acting as an ectoenzyme, catalyzing the conversion of nicotinamide adenine dinucleotide (NAD +) into nicotinamide, adenosine diphosphate–ribose (ADPR), and cyclic ADPR. CD38 is expressed on many types of cells, but recent interest focuses on its role on B lymphocytes.
CD38 and Regulation of the Immune Response Cells in Cancer
CD38, primarily a NAD + glycohydrolase and ADPR cyclase, is a multifunctional transmembrane protein whose abnormal overexpression in a variety of tumor types is associated with cancer progression.
CD38 - an overview | ScienceDirect Topics
CD38 is a multifunctional ectoenzyme found in hematopoietic cells, involved in regulating cell activation and proliferation. It is expressed in various hematopoietic cells such as committed stem cells, precursor B cells, and activated T cells, as well as at high levels on plasma cells.
Structure and Enzymatic Functions of Human CD38 - PubMed …
CD38 is a novel multifunctional protein that serves not only as an antigen but also as an enzyme. It catalyzes the metabolism of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate, two structurally and functionally distinct Ca2+ ...
CD38: A Significant Regulator of Macrophage Function - PubMed …
Cluster of differentiation 38 (CD38) is a cell surface glycoprotein and multifunctional extracellular enzyme. As a NADase, CD38 produces adenosine through the adenosine energy pathway to cause immunosuppression.
CD38 — a new target in renal immune disease - Nature
2024年7月23日 · Targeting of CD38 has been posited as a potential therapeutic avenue for the treatment of immune-mediated conditions. A phase 2 study now reports promising safety, tolerability and intermediate...