Slipped strand mispairing (SSM, also known as replication slippage) is a mutation process which occurs during DNA replication. It involves denaturation and displacement of the DNA strands, resulting in mispairing of the complementary bases.

2024年11月23日 · Slipped strand mispairing (SSM) is a process that produces mispairing of short repeat sequences during DNA synthesis. Explain how slipped-strand mispairing can be used as a mechanism to regulate gene expression.

Slipped Strand Mispairing, also known as polymerase slippage or replication slippage, refers to the temporary dissociation of the DNA polymerase and newly synthesized DNA strand complex from the template DNA during replication.

It has been shown that a functional mismatch repair system reduces the STR mutation rate between 100 and 1,000 folds (26). Thus, the observed STR mutation rate depends on the rate of slippage and the efficiency of the repair system correcting the mismatches.

The global mechanism that likely generates mutations in VNTR loci is slipped strand mispairing (Levinson and Gutman, 1987; Eisen, 1999). These insertion-deletion (INDEL) mutations occur at varied rates in VNTR loci, ranging from <10 −5 to >10 −4 in B. anthracis and exceeding 10 −3 in other bacteria (Vogler and Keim, unpublished data).

Slipped-strand nucleotide mispairing can generate variation in gene expression. Illegitimate base pairing in regions of repetitive DNA during replication, coupled with inadequate DNA...

We propose that slipped-strand mispairing events, in concert with unequal crossing-over, can readily account for all of these features. The frequent occurrence of long tandem repeats of particular motifs (polypyrimidine and poly-CA tracts) appears to result from nonrandom patterns of nucleotide substitution.

1987年6月1日 · We propose that slipped-strand mispairing events, in concert with unequal crossing-over, can readily account for all of these features. The frequent occurrence of long tandem repeats of...

1998年8月5日 · Mutations in 3′ exonucleases stimulate deletion formation via different mechanisms. A proposed intermediate of either a simple template slippage or an SCE-associated deletion event involves a stalled replication fork (Fig. (Fig.1). 1 ).

2024年9月12日 · Mechanism: Alkylating agents introduce alkyl groups to DNA bases, causing cross-linking and mispairing. This results in mutations that can disrupt normal DNA replication and function.