Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced its 2025 priorities and upcoming ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in ...

Funding – BBSRC funded 4-year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £19,237 Start Date – September 2025 Applicants are expected ...

Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor ...

Signalling through the ERBB/HER receptors ... that is aimed at increasing network robustness. The primordial receptor tyrosine kinase (RTK) might have been formed through a gene-fusion event ...

Furthermore, it was shown that LPA induces a transient increase in MLC phosphorylation and that the effect of LPA on barrier function was mediated by Rho kinase. Rather high concentrations of LPA were ...