D tumoroid models transform cancer research, accurately reflecting tumor biology and enabling effective drug testing and ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced its 2025 priorities and upcoming ...

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with its signaling diversity owing to the many substrates of extracellular signal-related kinase (ERK). AF6 denotes afadin, GAP GTPase-activating protein, GEF guanine exchange factor, MEK mitogen ...

Intracellular kinases play a ubiquitous role in signaling pathways within cells. Receptor tyrosine kinases function at the beginning of a number of signal transduction cascades, whereas ...

Additionally, silencing AURKA suppressed the glycogen synthase kinase-3β/β-catenin signaling pathway. Pharmacological inhibition of AURKA phosphorylation also resulted in reduced liver fibrosis in ...

Furthermore, it was shown that LPA induces a transient increase in MLC phosphorylation and that the effect of LPA on barrier function was mediated by Rho kinase. Rather high concentrations of LPA were ...

This unique mechanism allows avutometinib to block MEK signaling without the ... two members of the focal adhesion kinase family of non-receptor protein tyrosine kinases. FAK and Pyk2 integrate ...

Figure 5: Cell-survival pathways downstream of activated erbB receptor tyrosine kinases. The Ras–MAPK (mitogen-activated protein kinase) pathway is another important cell-proliferation pathway ...

More than 60 years after its discovery, the estrogen receptor (ER) remains the most important biomarker in ... and upregulation of growth factor signaling inducing hyperactive mitogen-activated ...

In this issue of Circulation Research, Wan et al identify the MER tyrosine kinase receptor as an engulfment receptor important for the clearance of cellular debris generated during acute cardiac ...