including rapid development of drug resistance (as seen with other tyrosine kinase inhibitors, such as imatinib). Relapses may also be due to the presence of several heterogeneous cell clones in ...

Operationally, mutated proteins that induce the development of the leukemic phenotype (oncogenes ... multiple pathways in the same leukemic cell. Tyrosine kinases are important elements of ...

Biopharmaceutical and Regenerative Sciences, Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan ...