p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

One helper in this process is the p53 protein. However, when it mutates, it can no longer fulfil its task. Until now, researchers have assumed that the process is the same with all mutation types.

Among their other tasks, members of the JDP family assist in the folding of the p53 protein, which is known as the "guardian ...

Kymera Therapeutics Inc. has published the characterization of KT-253, a novel compound designed to degrade the murine double minute 2 (MDM2) protein, offering a promising approach for cancers ...

Likewise, our findings demonstrate that wood smoke could produce similar effects on p53, phospho-p53, and MDM2 protein expression as tobacco.