Muscarinic acetylcholine receptors (mAChRs) are a type of receptor in the brain that respond to the neurotransmitter acetylcholine. They play a crucial role in various brain functions, including ...

The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...

The M1/M4 muscarinic receptor agonist is vying to be the first drug to reach the market for schizophrenia with a new mechanism of action in decades. It is also in phase 3 clinical testing as an ...

Trospium is a muscarinic receptor-blocking drug that can't traverse the blood-brain barrier, so the addition of that drug to the mix reduces the unpleasant side effects in the body. Cobenfy has ...

Telephone 0081 43 222 7171 ext 5414; fax 0081 43 226 2160; emailmasatoasahina{at}msn.com OBJECTIVES To assess muscarinic acetylcholine receptors (mAChRs) in the brains of patients with progressive ...

The drug – a selective muscarinic M4 receptor positive allosteric modulator (PAM) – is designed to have limited effect on dopamine neurotransmission, a mechanism thought to contribute to ...

Our recent work (McQuail & Burk, 2006) suggests that cholinergic muscarinic receptors, particularly the muscarinic M1 receptor, are important for mediating the effects of the cortical acetylcholine on ...

Xanomeline and trospium chloride (KarXT), a novel M1/M4 muscarinic receptor agonist, significantly improves cognitive ...

It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3 receptors at the smooth muscle leading to ...