Frizzled (FZD) receptors are key players in a pathway called Wnt that promotes malignant cell growth, making them a promising ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

In this manuscript Luo et al uncover that the ZNRF3/RNF43 E3 ubiquitin ligases participate in the selective endocytosis and degradation of FZD5/8 receptors in response to Wnt stimulation.

Signaling is initiated by the binding of Wnt to a Frizzled receptor as well as a low-density lipoprotein receptor-related protein (LRP) coreceptor (e.g., LRP5) but is inhibited by the binding of ...

Hair follicle stem cells (HFSCs) are influenced by β-catenin signaling, where Wnt proteins bind to receptors such as LRP and Frizzled, activating Disheveled and preventing β-catenin degradation.