Numerous investigations showed that tumors exhibit different levels of ferroptosis-related genes and proteins, including ACSL4, arachidonate lipoxygenase 15 (ALOX15), ATP synthase, H+ transporting, ...

Background and aims: Ferroptosis, a novel concept of programmed cell death proposed in 2012, in kidney disease, has garnered significant attention based on evidence of abnormal iron deposition and ...

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...

School of Basic Medical Sciences, Binzhou Medical University, Yantai 264003, China ...

Among the other pathways, ferroptosis was notably prominent, and the glutathione metabolism pathway ... RNA was extracted and genes such as GPX4, SLC7A11, FTH1, PTGS2, ACSL4, were quantified by qPCR ...

高度近视在全球的患病率呈上升趋势，已成为严峻的健康挑战。高度近视性白内障作为高度近视最常见的并发症，发病年龄比年龄相关性白内障更早，严重影响患者工作期间的生活质量。由于晶状体核通常较硬，HMC 的手术干预难度较大，因此深入了解其发病机制对开发潜在治疗方法至关重要。

过往“肠脑轴”研究多聚焦于肠道菌群分泌的小分子代谢物，如短酸、神经递质等物质影响脑部疾病发生，而首都医科大学基础医学院张晨/王伟/刘希成教授团队2024年11月在 Cell Metabolism （IF27.7）上发表了题为“Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via ...

铁死亡（Ferroptosis）是一种受控的非凋亡细胞死亡新形式 ... TNBC 还表现出与铁死亡相关的异常基因表达模式，包括铁代谢相关的转铁蛋白受体和脂代谢相关的 ACSL4 表达上调，以及铁输出转运蛋白的表达下调。这些失调的基因表达，特别是在铁和脂质代谢方面 ...