In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

Dr. David A. Braun delved into the molecular factors which drive exceptional responses to immunotherapy in metastatic clear cell renal cell carcinoma.

Recent research led by Associate Professor of Biological Sciences Aleksandar Necakov gives insight into the workings of the Notch receptor protein, implicated in the spread of cancer cells. A ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...

receptor specificity in the receiving cells and intracellular signal transduction cascades. Signalling cross talk in cell differentiation and how particular signals control the development of specific ...

3A). Interestingly, this blunt phosphorylation of insulin receptors and Akt was rescued upon TRIM32 knockdown in HI condition in mouse primary hepatocytes (Fig. 3B). Collectively, these results ...

Lutris Pharma, a clinical stage biopharmaceutical company focused on improving anti-cancer therapies by reducing cutaneous ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.