Now, in 2025, a lost icon of its ’70s catalogue is enjoying a contemporary re-release – one that refines a celebrated collection for today’s discerning palates. Whilst it only enjoyed a ...

2025年1月14日，人用药品技术要求国际协调理事会(ICH)官方发布了ICH E6 (R3)终稿。本次修订后，ICH GCP E6(R3)已经到达第四阶段。Step 4的最终文件由ICH大会的监管成员作为ICH harmonised guideline在Step 4阶段采纳，即将进入Step 5 Implementation 正式实施。E6(R3)强调简单高效 ...

Back in the day (let’s say up through the 1990s and into the 2000s) the Holy Trinity was a delineation of the three very best Swiss mechanical watchmakers, each of which had built its reputation ...

Three years after releasing the Yellow Gold 222, Vacheron Constantin has outdone itself yet again, unveiling the Historiques 222 in stainless steel. Launched to kick off its 270th-anniversary ...

While it is not a limited edition, you can safely assume the $32,000 steel 222 will be hard to get. Will it be more challenging to obtain than a Patek Philippe Nautilus or an Audemars Piguet Royal ...

Every product is carefully selected by our editors. If you buy from a link, we may earn a commission. Learn more For the better part of the last decade, the most hyped genre of watch has been ...

The much-anticipated watch made it to Fratello HQ ahead of the embargo. It was a perfect way to experience firsthand if the revamped 1970s icon in steel lived up to all of our high expectations. If ...

PBS Passport streaming expires February 17, 2028 @ 11:59 PM ET With the War feeling closer to home, James desperately wants things in order and Carmody trained up to support Siegfried. Carmody and ...

You may often notice blank icons on your desktop or folders or incorrect images on your Windows 11 device. These are broken icons in Windows 11/10, and we have just the right solutions for you to ...