HER2-negative breast cancers are HER2-low and potentially an additional 25% may be HER2-ultra-low. There are no targeted therapies specifically approved for patients with HER2-ultra-low expression ...
Stratification factors included prior CDK4/6 inhibitor use (yes vs no), HER2 expression (low vs ultra-low), and prior taxane use in the non-metastatic setting (yes vs no). The primary end point was ...
Enhertu is approved for HR-positive, HER2-low or -ultralow metastatic breast cancer after endocrine therapy progression, based on DESTINY-Breast06 trial results. Enhertu showed a 36% reduction in ...
T-DXd has received FDA approval for the treatment of unresectable or metastatic HR+, HER2-low/-ultralow breast cancer in patients whose disease progressed on prior endocrine therapy in the metastatic ...
Roche’s PATHWAY anti-HER2/neu (4B5) Rabbit Monoclonal Primary Antibody test becomes the only FDA approved companion diagnostic indicated to aid assessment of HER2 low-metastatic breast cancer ...
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(AZN.L, AZN) and Daiichi Sankyo's (DSKYF.PK) ENHERTU (fam-trastuzumab deruxtecan-nxki) for the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, HER2-low ...
“Human epidermal growth factor receptor 2 (HER2)-low breast cancer has recently emerged as a new clinical subtype of breast cancer, benefiting from treatment with novel anti-HER2 antibody-drug ...
A new review was published in Oncotarget's Volume 16 on January 20, 2025, titled "Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms." Researchers ...
The accelerating need for ever higher data rates and serial I/O density sets demanding performance requirements for current and next generation SerDes transceivers. Not only must they handle multiple ...
Abstract: Antenna patterns with ultra-low sidelobes have been obtained for an experimental receiving array designed with time-modulated slot radiators. The technique utilizes on-off RF switches which ...