2Department of Pathology, University of Michigan, Ann Arbor, Michigan. 3Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan. Search for other works by this author on: 1Michigan Center for ...

Immunotherapy, cancer treatments that alter the immune system, making it better apt to fight tumor cells, have provided novel ...

As they expand, the malignant cells chip away at the body’s immune defenses. Scientists have always assumed mitochondria are produced inside cells and live out their lives there. The new findings ...

Molecular Zip Code Draws Killer T Cells Straight to Brain Tumors Dec. 5, 2024 — Scientists have developed a 'molecular GPS' to guide immune cells into the brain and kill tumors without harming ...

These data explain the molecular basis of tumor immune evasion in hypoxic conditions, and have implications for future therapeutic interventions targeting hypoxia-induced alterations in antigen ...

Endosomal escape and removal through macrophages of lipid nanoparticles is possible without ... benefit in multiple cancer ...

This strategy not only intensifies immune responses but also improves the durability of treatment by overcoming tumor immune escape mechanisms. Despite the immense potential of VLPs in cancer ...

This therapy is the first to activate specific components of the adaptive immune system, particularly CD4+ T helper cells, which are not known to be involved in traditional cancer treatments.

However, the impact of complex tumor-infiltrating immune cell profiles on responses to immune checkpoint ... For young patients, the focus should be on strategies that restore CD8+ T cell function, ...