Toll-like receptors (TLRs) are proteins that recognize specific molecular patterns of pathogens. They can also interact with a variety of endogenous ligands. When stimulated, TLRs initiate a ...

Stewart, C. R. et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nature Immunology 11,155–161 (2010) doi:10.1038/ni.1836. Takeuchi ...

Toll-like receptors (TLRs) are one of the largest and ... Activation of TLR signaling by viral ligands establishes primarily antiviral responses. However, certain viral infections develop TLR ...

“The overall conclusion is that, through one innate immune receptor, with two different ligands, you can trigger two different types of outcome.” LPS, also known as endotoxin, is a molecule found in ...