Instead, these effects are mediated through other receptors, such as the thromboxane and E prostanoid receptors[2]. This highlights the complexity of prostaglandin signaling and its implications ...

Expert Rev Clin Pharmacol. 2012;5(3):319-336. †There are controversial data concerning prasugrel resistance, and there is a need for larger studies to confirm prasugrel resistance. IPA ...

Dr. Ruan’s pioneering work extended to active single-chain GPCR-G-protein complexes. By linking G-protein-coupled receptors (GPCRs), such as thromboxane A2 and prostaglandin E2 receptors, to specific ...

Endothelial dysfunction is one manifestation of the many changes induced in the arterial wall by the metabolic abnormalities accompanying diabetes and insulin resistance. In type 1 diabetes ...

Expert Rev Clin Pharmacol. 2012;5(3):319-336. Aspirin improves clinical outcome in all cardiovascular (CV) syndromes in primary and secondary prevention, including acute events. In high-risk ...

Background: Patients with vitamin D deficiency are susceptible to increased microbial infection and increased risk of mortality. However, whether vitamin D supplementation would improve their ...

Correspondence to Dr Ailsa Hart, IBD Unit, St Mark's Hospital and Imperial College London, Watford Road, London HA13UJ, UK; ailsa.hart{at}nhs.net Over the last 10–15 years, our understanding of the ...

In the HIS group, 6-keto-PGFα, 15-deoxy-d-12,14-PGJ2, and thromboxane B2 were downregulated, while arachidonic acid was upregulated. In the IC-HIS group, arachidonic acid and 5,6-DHET were upregulated ...

When thrombin was generated by the blood coagulation reaction, the platelets were activated by the thrombin through the thrombin receptor PAR-1 pathway. Such platelets could greatly contribute to the ...