Single-cell RNA sequencing (scRNA-seq) research of mouse and human CD8 + T cells revealed a surprising population of distinct age-related CD8 + T cells (5). Similarly, scRNA-seq from aged and young ...

R package with collection of functions created and/or curated to aid in the visualization and analysis of single-cell data using R.

Objective Innate immunity plays important roles in pancreatic ductal adenocarcinoma (PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune system. Here, we aimed to ...

Here, we report a systematic transcriptional atlas to delineate molecular and cellular heterogeneity in GA using single-cell RNA sequencing (scRNA-seq). Design We performed unbiased transcriptome-wide ...

Scientists gain valuable insights into cellular diversity and functions, disease mechanisms, developmental processes, and drug responses by examining the transcriptome of tissues using single-cell RNA ...

The immune cells are postulated to exert a pivotal role in the development of fibrotic skin disease. Single-cell RNA sequencing has been used to explore the composition and functionality of immune ...

Single nucleus RNA sequencing (snRNA-seq), an alternative to single cell RNA sequencing (scRNA-seq), encounters technical challenges in obtaining high-quality nuclei and RNA, persistently hindering ...

Thus, they do not necessarily follow the latest best practices for scRNA-seq analysis anymore. For an up-to-date version of the latest best practices for single-cell RNA-seq analysis (and more ...

Objectives SLE is a multifaceted autoimmune disorder with a complex pathogenesis involving genetic, environmental and hormonal factors, which converge on immune dysregulation. The T cell receptor (TCR ...

Sickle cell disease (SCD) with concurrent systemic lupus erythematosus (SLE) is an uncommon but significant association requiring heightened clinical awareness, according to results from a ...