NNRTIs bind to a hydrophobic pocket near the catalytic site of HIV-1 RT and inactivate enzymatic activity. NNRTI-resistance mutations & their mechanism ... and an RNase H domain.

CREATE operates entirely through RNA components without requiring DNA donor templates or double-strand breaks. CREATE incorporates multiple built-in checkpoint mechanisms to ensure precise on-target ...

The findings shed light on how socio-sexual preferences adapt for survival and health in mammals. Understanding these neural mechanisms could inform studies on social behavior and stress responses in ...

When Johnny Wactor found three people in masks trying to steal the catalytic converter from his Toyota Prius last May, one of the thieves yelled “No!” before his “hot-headed” companion ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

Centre for Engineering Biology, Institute of Quantitative Biology, Biochemistry and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FF, U.K. Centre for ...

Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria ...

This important study addresses how 3' splice site choice is modulated by the conserved spliceosome-associated protein Fyv6. The authors provide compelling evidence Fyv6 functions to enable selection ...

time of day, fore/hindmilk collection, duration and temperature of storage); laboratory analysis methodology; child or maternal health outcomes (as appropriate); suggested target predictions and ...