Preclinical studies have indicated several molecular mechanisms that could contribute to the development of trastuzumab resistance. Increased signaling via the phosphatidylinositol 3-kinase/Akt ...

Th e GINECO trial explored the combination of trastuzumab with paclitaxel and carboplatin in patients with resistant AOC (< 6 months) and HER2 gene amplification. Patients and Methods: A total of ...

Importantly, this mechanism is disrupted in breast cancer cells resistant to trastuzumab, a common treatment for HER2-positive breast cancer, offering valuable insights into why some breast cancers ...

Women with high-risk HER2-positive breast cancer lived significantly longer with adjuvant trastuzumab emtansine (T-DM1, Kadcyla), according to long-term follow-up of a large clinical trial. Estimated ...

Antibiotic resistance is the ability of bacteria to resist the effects of antibiotics, a type of drug - such as penicillin or ciprofloxacin - that kills or stops the growth of bacteria. When bacteria ...

However, there are ways to get needed support to get you past resistance. Nonprofits like Family Caregiver Alliance are a good place to start.

Polycystic ovary syndrome (PCOS) can put you at risk for insulin resistance. Watch for symptoms of insulin resistance that are common for females with PCOS. These include cravings and frequent ...

Sniper Elite: Resistance may not innovate much on the series' standard blueprint, but it's still a challenging, rewarding, and deeply satisfying adventure. I love killing stuff. Always have.

A march, in and of itself, is not going to solve the problem. But that doesn’t mean the resistance won’t exist,” said Dana Fisher, an American University professor and the author of ...

The primary analysis of KATHERINE, a phase 3, open-label trial, showed that the risk of invasive breast cancer or death was 50% lower with adjuvant trastuzumab emtansine (T-DM1) than with ...

More information: Survival with Trastuzumab Emtansine in Residual HER2-Positive Breast Cancer, New England Journal of Medicine (2025). DOI: 10.1056/NEJMoa2406070 Provided by University of Pittsburgh ...