Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced its 2025 priorities and upcoming ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in ...

Funding – BBSRC funded 4-year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £19,237 Start Date – September 2025 Applicants are expected ...

Signalling through the ERBB/HER receptors ... that is aimed at increasing network robustness. The primordial receptor tyrosine kinase (RTK) might have been formed through a gene-fusion event ...

Figure 1: a, Sequence alignment of SAM domains from the Eph family of receptor tyrosine kinases and selected ... other protein interaction modules with signaling functions such as SH3, SH2 ...

This unique mechanism allows avutometinib to block MEK signaling without the ... two members of the focal adhesion kinase family of non-receptor protein tyrosine kinases. FAK and Pyk2 integrate ...

Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University, Otsu, Shiga 520-0811, Japan Key Laboratory of Industrial Ecology and Environmental Engineering ...

The study highlights adhesion G-protein-coupled receptor A3 (ADGRA3) as a potential target for activating adaptive thermogenesis ... (F and H) Western-blot analysis for level of p-CREB and CREB ...

FIGURE 1. Different structural types of small-molecule MET kinase inhibitors. We focused on the design of new antiproliferative agents with potential interactions with MET active site as type II ...

What is the essential forward-grade signaling mechanism used by the receptors that cause vascular mitochondrial fragmentation ... smooth muscle 22 α; and Tie2, tyrosine kinase with immunoglobulin like ...

In this issue of Circulation Research, Wan et al identify the MER tyrosine kinase receptor as an engulfment receptor important for the clearance of cellular debris generated during acute cardiac ...