“Both pathways are known to have important roles in the RA synovium, and to be TNF-dependent,” notes Lauwerys. “Our study demonstrates for the first time that they are major targets of TNF ...

In the fetal tissues, ROL is converted to retinal and then to retinoic acid (RA) by the embryonic retinaldehyde dehydrogenase (RALDH) 2 (6). In mice, targeted disruption of Raldh2 arrests ...

Evan Y. Yu, MD, discusses the design and objectives of the phase 3 PEACE 3 study, which evaluates the combination of enzalutamide (ENZA) and radium-223 (Ra-223) in androgen receptor pathway inhibitor ...

more aggressive use of DMARDs and new classes of disease-modifying biologic medications that target the specific pathways responsible for RA. The updated 2021 American College of Rheumatology ...