Importantly, ManS was produced by a noncanonical biogenesis mechanism: The ribonuclease RNase III, which usually cuts double-stranded RNA, cleaves at a single-stranded region in the mRNA 3'UTR.

"Seeing the RNase Z complex in such detail is like watching ... providing us with invaluable insights into the precise mechanisms of tRNA maturation." One key finding is the discovery of the ...

Five unrelated kids from four countries - Turkey, Spain, the Philippines, and Canada - shared mutations in three closely related genes controlling the OAS-RNase L pathway, which is involved in ...