DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted ...

Bacterial RNA polymerase (RNAP) is a crucial enzyme responsible ... has been studied to reveal its structural interactions with RNAP and promoter DNA. Cryo-electron microscopy (cryo-EM) studies ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...

This is a molecular machine which can read DNA and create a matching strand of RNA which is then used to make proteins. RNA polymerase binds to a region just before the gene, called the promoter, ...

Several types of RNA help regulate gene expression ... and thus can bind those regions to facilitate polymerase recruitment and DNA looping, which brings the transcription machinery into contact with ...

Promoter Shareholding Boost: A data page highlighting companies where major stakeholders raise ownership stakes, signaling confidence in long-term growth ...

In recent years, quantitative real-time PCR tests have been extensively developed in clinical microbiology laboratories for routine diagnosis of infectious diseases, particularly bacterial ...

Total RNA was extracted from cells using PureZol (Cat# 7326880 BioRad), according to the ... cDNA was examined by semiquantitative PCR, conducted in the automated DNA Thermal Cycler GeneAmp PCR System ...

This work highlights the importance of the non-coding transcriptome in supporting oncogenic pathways, and reinforces the need to globally characterise non-coding RNA expression patterns and functions.

Exon: coding part of a gene; those parts of a gene that are found in the mature messenger RNA (mRNA). Genotype: genetic constitution of an individual ... we will focus on two basic techniques that are ...