In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and ...

there is a clear difference in orientation after the ligand (substrate/inhibitor) binding domain. Thus, a better understanding of the differences will provide valuable insights for the search and ...

H. et al., 2016). A hybrid QM/MM solute was also used in MMPBSA applications for predicting the binding affinities of FabI inhibitors (Su et al., 2015). The study suggested that the prediction results ...

Inhibition of apoptosis has mixed effects ... Once activated, caspases cleave their substrates after conserved aspartate residues. The effects of caspases on cellular substrates bring about ...

This manuscript describes an important finding of the transcriptional control of a chimeric gene transfer agents (GTA) cluster in Bartonella by a processive anti-termination factor (BrrG). The ...

Graduate School of Life Science and System Engineering, Kyushu Institute of Technology, 2-4, Hibikino, Wakamatsu, 808-0196 Kitakyushu, Japan ...

Quantitative and qualitative changes in matrix protease activity play an important ... specifically degrade collagens and noncollagenous substrates (see [37] for review). Broadly, these enzymes ...

Objective Polymorphisms in the antifungal signalling molecule CARD9 are associated with ankylosing spondylitis (AS). Here, we investigated the cellular mechanism by which CARD9 controls pathogenic ...