Mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine protein kinase, serves as a central regulator of cell growth, proliferation, and survival by coordinating nutrients, ...

and found that KO of heterozygous p53-R280T significantly decreased NPC cell proliferation and increased NPC cell apoptosis, whereas KO of wild-type p53 had opposite effects on NPC cell proliferation ...

Background While p53 mutations occur early in Barrett’s oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear. Objective This study ...

A study published by the Journal of Traditional and Complementary Medicine and e-published by the U.S. National Library of Medicine highlights cannabidiol’s (CBD) potential as a therapeutic option for ...

The C-terminal 19 amino acids of wild type p53 suppress the p53 response at sublethal doses of radiation. In contrast to cancer cells, mutant p53 activities are not well defined in nonmalignant cells.

Thus, an emerging strategy for the treatment of those conditions is to inhibit cellular proliferation by targeting cell cycle regulation. Here we will review the current understanding of the ...

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

Mitogenic growth factors share a final common signalling pathway: the cell cycle (Fig. 2). Quiescent (G0) cells enter a gap period (G1), during which the factors necessary to DNA replication for ...