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Dr. Moyle and Dr. Mitchell answer criticisms of their interpretation of tests of the hypothesis proposed by Dr. Mitchell in 1961 to explain ATP synthesis in the inner membrane of mitochondria and ...

azl{at}po.cwru.edu BACKGROUND The pathogenesis of non-steroidal anti-inflammatory drug (NSAID) enteropathy is complex. It involves uncoupling of mitochondrial oxidative phosphorylation which alters ...

A critical factor in this devastating disease is the metabolic reprogramming exhibited by cancer cells, particularly the preference for aerobic glycolysis over oxidative phosphorylation ...

Mitoribosomes are present in the mitochondria of all eukaryotic cells. Their function is to allow the translation of mitochondrial mRNA that exclusively encodes components of the oxidative ...

As a consequence of recent research undertaken in a number of different countries, using a range of different approaches, oxidative stress has been identified as a unifying feature underlying the ...

There is substantial evidence that differential cancer cell metabolism, and oxidative phosphorylation (OxPhos) in particular, plays a key role in the development of resistance to current therapies.

Loss of SMAD4 induces PGK1 upregulation in PDAC, which enhances glycolysis and aggressive tumour behaviour. Notably, in SMAD4-negative PDAC, nuclear PGK1 preferentially drives cell metastasis via ...

New research highlights the promise of a novel stem cell treatment strategy for leptomeningeal brain metastasis (LBM), a ...

It then very quickly forms a complex with the two components of the enzyme nitrogenase, which protects them from oxidative damage. In this process, the activated Shethna protein II binds the much ...