Cut off any part of this worm's body and it will regrow. This is the spectacular yet mysterious regenerative ability of ...

Limiting-dilution cell transplantation revealed that Notch signaling does not increase the overall frequency of leukemia-propagating cells (LPCs), either alone or in collaboration with Myc.

The data also revealed an association between age-related bone degeneration and a significant upregulation of Notch signaling genes, suggesting that this pathway becomes abnormally active in SSPC as ...

Taken together, all these results suggest that Hes1 functions downstream to Notch signaling for the suppression of AML development in mice.

Specifically, we would like to understand how these glycosyltransferases regulate the activity of the Notch signaling pathway in a dosage-sensitive and tissue-specific manner. We have reported a mouse ...