Mitogen-Activated Protein Kinase (MAPK) signaling pathways play a crucial role in various cellular processes, including growth, differentiation, and response to stress. These pathways are ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

MAP2K1 mutations have been functionally classified into three groups according to their dependency on upstream RAS/RAF signaling. However, the clinical efficacy of mitogen-activated protein kinase ...

Mitogen-activated protein kinases (MAPKs) in tomato plants have crucial functions of mediating ... altering their binding affinity to the promoter regions of target genes and thereby suppressing or ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... in cancers results in the activation of several downstream pathways that are shared with other tyrosine kinases.

Researchers have discovered how a particular protein affects the growth and spread of colon cancer in humans. The study not ...

Lutris Pharma, a clinical stage biopharmaceutical company focused on improving anti-cancer therapies by reducing cutaneous ...

The studies suggest that mutant KRAS signals predominantly through the rapidly accelerating fibrosarcoma (RAF) effector pathway ... MEK mitogen-activated protein kinase kinase, MT mutant, Pi ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...