For example, 45 human protein kinases lack at least one of the conserved catalytic residues 2 and may not have kinase activity. Kinase activity has not been detected for several CDK-related ...

Among these, RAF1 S257, S259, G361, and R391 mutations are oncogenic or likely oncogenic mutations that confer increased kinase activity. 35 Conversely, among 66 class 3 MAP2K1-mutated tumors, no RAF1 ...

Researchers from the Nagoya University Graduate School of Medicine identified an enzyme, alpha-kinase 2 (ALPK2) that is ...

Erlotinib is a quinazoline derivative that selectively and reversibly inhibits the tyrosine kinase activity of the EGFR. Here, we review the mechanism(s) of action of erlotinib, as well as the ...