Multi-Modal Models: A multi-modal discovery approach was implemented that engineered-in potency against the novel target and engineered-out a specific off-target interaction. The NCE library displayed ...
Two new compounds may be able to treat retinitis pigmentosa, a group of inherited eye diseases that cause blindness. The compounds were identified using a virtual screening approach.
Tests showed that the identified compounds prolonged the survival of photoreceptors in a retinitis pigmentosa mouse model for rod opsin misfolding, and protected retinas against light-induced ...
A risk model comprised of 18 mitochondria-related genes (MRGs) offers the potential to provide personalized prognostic assessment and to guide treatment for patients with diffuse large B-cell lymphoma ...
The compounds, described in a study published January ... mutants in vitro and slow photoreceptor cell death in a mouse model of RP, offering a potential new therapeutic approach to prevent ...