The tumor suppressor p53 is activated upon multiple cellular stresses, including DNA damage, oncogene activation, ribosomal stress, and hypoxia, to induce cell cycle arrest, apoptosis, and senescence.

In recent years, scientific exploration has increasingly focused on the potential advantages of intentional exposures to environmental stressors, such as cold, heat, and hypoxia (Brunt and Minson, ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Gene expression analyses indicated a downregulation of critical wound healing markers, including HIF-1α, VEGF, IL-8, and FAK, suggesting effective alleviation of hypoxia, inhibition of angiogenesis, ...

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State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, and MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR ...

Dyspnea can be associated with hypoxia or hypoxemia, which is low blood oxygen levels. This can lead to a decreased level of consciousness and other severe symptoms. If a person experiences ...

Objective Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with limited treatment options. Cabozantinib, an orally bioavailable multikinase inhibitor is now approved by ...