Chromatin, the mix of DNA and protein that houses each cell's genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by ...
Histones consisting of H2A, H2B, H3, and H4 are proteins that are critical in the packing of DNA into the cell. Lysine residues in N-terminal tails of histone H3 are the major targets for ...
This highlights one of the current limitations of the preliminary CG model presented here. Conversion between different compacted states of 30 nm chromatin significantly depend on the histone tails, ...
Replication-dependent histone mRNAs, which encode the most abundant histone proteins, are the only known cellular mRNAs that are not polyadenylated. Instead they end in a conserved stem–loop ...
Chromosome segregation relies on kinetochores that assemble on specialized centromeric chromatin containing a histone H3 variant. In budding yeast, a single centromeric nucleosome containing Cse4 ...