Study of 2.4 million participants reveals potential advantages for cardiometabolic and psychiatric conditions alongside increased risks of gastrointestinal and musculoskeletal issues Study ...

In this manuscript Luo et al uncover that the ZNRF3/RNF43 E3 ubiquitin ligases participate in the selective endocytosis and degradation of FZD5/8 receptors in response to Wnt stimulation.

This research will be of interest to biologists specializing in Wnt signaling, cancer, and regenerative medicine. Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway.

Signaling is initiated by the binding of Wnt to a Frizzled receptor as well as a low-density lipoprotein receptor-related protein (LRP) coreceptor (e.g., LRP5) but is inhibited by the binding of ...

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