In this manuscript Luo et al uncover that the ZNRF3/RNF43 E3 ubiquitin ligases participate in the selective endocytosis and degradation of FZD5/8 receptors in response to Wnt stimulation.

Frizzled (FZD) receptors are key players in a pathway called Wnt that promotes malignant cell growth, making them a promising ...

This research will be of interest to biologists specializing in Wnt signaling, cancer, and regenerative medicine. Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway.

Signaling is initiated by the binding of Wnt to a Frizzled receptor as well as a low-density lipoprotein receptor-related protein (LRP) coreceptor (e.g., LRP5) but is inhibited by the binding of ...

Personalized Medicine. 2010;7(6):655-668.

Hair follicle stem cells (HFSCs) are influenced by β-catenin signaling, where Wnt proteins bind to receptors such as LRP and Frizzled, activating Disheveled and preventing β-catenin degradation.

Texas A&M Drug Discovery Center, Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States Institute of Biosciences and Technology and Department of Translational ...

EYE-103 is under clinical development by Eyebiotech and currently in Phase III for Diabetic Macular Edema. According to GlobalData, Phase III drugs for Diabetic Macular Edema have a 62% phase ...

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